Cisplatin-induced aki

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August undefined, 2024

Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH … WebAim: This study was carried out to identify the expression profile and role of circRNAs in cisplatin-induced acute kidney injury (AKI).Materials & methods: In this study, an AKI model was established in cisplatin-treated mice, and the expression of circRNAs was profiled by next-generation sequencing. The differential expression levels of selected …

Doseâ Dependent Protection by Lipoic Acid against Cisplatinâ …

WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. In this study, we gave a single peritoneal injection of CP followed by high (2% ... WebPurpose: Cisplatin-induced acute kidney injury (CIA) is a serious adverse event that affects 20-40% of exposed patients, despite any implemented precaution to avoid … philips qled

PSTPIP2 inhibits cisplatin-induced acute kidney injury by …

WebMethods To investigate whether kidney-targeted delivery of renalase might prevent cisplatin-induced CKD in a mouse model, we achieved specific delivery of a renalase agonist peptide (RP81) to the renal proximal tubule by encapsulating the peptide in mesoscale nanoparticles (MNPs). We used genetic deletion of renalase, single-cell RNA … WebMar 15, 2016 · The standard mouse model of cisplatin-induced AKI consists of one high dose of cisplatin (>20 mg/kg) that is lethal to the animal 3 days later. This model does not accurately reflect the dosing regimen patients receive nor does it allow for the long-term study of kidney function and biology. We have developed a repeated dosing model … WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. Howe … philips qp2512 one blade trimmer / shaver

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

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WebDec 21, 2024 · The clinical use of cisplatin has been hampered by its dose-dependent side effects, e.g., nephrotoxicity, and the precise mechanism(s) related to such a cisplatin … Web3.1 Cisplatin-induced AKI (nephrotoxin) Researchers first learned that platinum compounds could prevent cell division in 1960s. The U.S. Food and Drug Administration … philips qp2520 30 oneblade rechargeableWebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, … philips pw

"WebApr 25, 2014 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. There is … " - Cisplatin-induced aki

Cisplatin-induced aki

Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute …

WebDec 12, 2024 · Cisplatin (CP) is an effective chemotherapeutic agent widely used in the treatment of various solid tumours. However, CP nephrotoxicity is an important limitation … WebSep 2, 2024 · Melatonin alleviates renal dysfunction in sepsis-induced acute kidney injury. 8-week-old mice were treated with melatonin (25 μg/ml) dissolved in drinking water for 14 days. ... Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats via Induction of Anti-Aging Protein, Klotho. Food Chem. Toxicol. 129, 201–210. …

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WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … WebDec 12, 2024 · Cisplatin can induce AKI through ischemic damage, by reducing the blood flow in the medulla of the kidneys leading to tubular cell injury. Vasoconstriction due to …

WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under … WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …

WebDec 16, 2024 · Introduction. Cisplatin (CDDP; cis-dichlorodiammine platinum [II]) is a non-specific drug of the cell cycle with strong cytotoxicity and broad-spectrum antitumor effects; it is widely used in urogenital system tumors, malignant lymphoma, breast cancer, head and neck cancer, non-small cell lung cancer, etc. (1–3) Cisplatin-induced nephrotoxicity is … WebFeb 24, 2024 · Through experiments with a cisplatin-induced AKI model in vitro and in vivo, Baliga et al. suggested that cisplatin treatment led to increased expression of non …

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … philips quality engineer hamburg linkedinWebsuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH ratio signiﬁcantly decreased with cisplatin treatment suggesting that cisplatin induced oxidative stress response in the kidney. GSH/oxidized GSH ratio is known to be an trworkshopWebAug 6, 2014 · The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, oxidative stress, inflammation, and vascular injury in the kidney. There is … philips qp2530/30 oneblade rechargeableWebFeb 24, 2024 · Through experiments with a cisplatin-induced AKI model in vitro and in vivo, Baliga et al. suggested that cisplatin treatment led to increased expression of non transferrin-bound iron . Additionally, deferoxamine (a chelating agent for removing excess iron) treatment significantly improved the functional and histological deterioration in ... philips qt4001/15 pro skin advance trimmerWebJan 3, 2024 · Cisplatin-induced acute kidney injury (CI-AKI) is a significant co-morbidity of chemotherapeutic regimens. While this condition is associated with substantially lower … trworld.co.krWebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … tr worksheetWebAug 6, 2014 · It may be concluded that, in cisplatin-induced AKI, activation of TLR4 on renal parenchymal cells may activate p38-MAPK pathways leading to nephrotoxicity . In summary TNF-alpha and IL-33 are proinflammatory cytokines that mediate cisplatin-induced AKI while IL-10 is an anti-inflammatory cytokine that protects against cisplatin … trw overton pattern